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> Pathway Inhibitors>Enzyme Inhibitors>Kinase Inhibitors>CHIR-99021 HCl

Kinase Inhibitors

CHIR-99021 HCl View larger

CHIR-99021 HCl

AT2310L

CAS 1797989-42-4

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$26.00

$26.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $22.10 Total: $110.50
110 $18.72 Total: $187.20
125 $15.86 Total: $396.50
150 $13.52 Total: $676.00
1100 $11.70 Total: $1,170.00

Data sheet

Molecular FormulaC22H19Cl3N8
Molecular Weight501.8
CAS Numbers1797989-42-4
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCl.N#CC1=CN=C(C=C1)NCCNC=2N=CC(C3=NC=C(N3)C)=C(N2)C=4C=CC(Cl)=CC4Cl
ReferencesRing DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52[3] 588-95.

More info

CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3??, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivity over CDC2, ERK2, and other protein kinases. Additionally, CHIR-99021 HCl serves as a robust activator of the Wnt?-catenin signaling pathway. Moreover, it exhibits the ability to enhance self-renewal in both mouse and human embryonic stem cells. Furthermore, CHIR-99021 HCl induces autophagy [1] [2] [3].

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