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View larger AMPK Activator 991 (Compound 991)
AOB8150
CAS No: 1219739-36-2
AOBIOUS launched this product in 2017
CITATIONS - Publications That Use AOBIOUS Product
1) Am J Physiol Endocrinol Metab. 1:315 (2018)
The FASEB Jounal 34:6284 (2020)
1528 Items
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $12.75 | Total: $63.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 100 | $6.75 | Total: $675.00 |
Data sheet
| Molecular Formula | C24H18ClN3O3 |
| Molecular Weight | 431.87 |
| CAS Numbers | 1219739-36-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | EX-229; EX 229; EX229; AMPK Activator 991 |
| IUPAC/Chemical Name | 5-{[6-chloro-5-(1-methylindol-5-yl)-1H-benzimidazol-2-yl]oxy}-2-methyl-benzoic acid |
| InChl Key | FHWSAZXFPUMKFL-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C24H18ClN3O3/c1-13-3-5-16(10-17(13)23(29)30)31-24-26-20-11-18(19(25)12-21(20)27-24)14-4-6-22-15(9-14)7-8-28(22)2/h3-12H,1-2H3,(H,26,27)(H,29,30) |
| SMILES Code | O=C(O)C1=CC(OC2=NC3=CC(C4=CC5=C(N(C)C=C5)C=C4)=C(Cl)C=C3N2)=CC=C1C |
| References | 1) Xu YY, Chen FL, Ji F, Fei HD, Xie Y, Wang SG. Activation of AMP-activated protein kinase by compound 991 protects osteoblasts from dexamethasone. Biochem Biophys Res Commun. 2017 Nov 21. pii: S0006-291X(17)32311-2. 2) Song Y, et al. Determination of a novel anticancer AMPK activator hernandezine in rat plasma and tissues with a validated UHPLC-MS/MS method: Application to pharmacokinetics and tissue distribution study. J Pharm Biomed Anal. 2017 Jul 15;141:132-139. 3) Willows R, Navaratnam N, Lima A, Read J, Carling D. Effect of different γ-subunit isoforms on the regulation of AMPK. Biochem J. 2017 May 9;474(10):1741-1754. |
More info
Novel AMPK activator, increasing AMPK activity of both AMPKgamma1- and AMPKgamma3-containing complexes in mouse skeletal muscle
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