Luminescent Probes

Fluorofurimazine View larger

Fluorofurimazine

AOB12875

CAS 2412089-96-2

Chemical Name: 6-(3-Amino-2-fluorophenyl)-8-(2-fluorobenzyl)-2-(furan-2-ylmethyl)imidazo[1,2-a]pyrazin-3(7H)-one

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Data sheet

Molecular FormulaC24H18F2N4O2
Molecular Weight432.43
CAS Numbers2412089-96-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymFluorofurimazine;
IUPAC/Chemical Name6-(3-amino-2-fluorophenyl)-8-(2-fluorobenzyl)-2-(furan-2-ylmethyl)imidazo[1,2-a]pyrazin-3(7H)-one
InChl KeyXXHFQEWHBDAKEA-UHFFFAOYSA-N
InChl CodeInChI=1S/C24H18F2N4O2/c25-17-8-2-1-5-14(17)11-19-23-29-20(12-15-6-4-10-32-15)24(31)30(23)13-21(28-19)16-7-3-9-18(27)22(16)26/h1-10,13,28H,11-12,27H2
SMILES CodeO=C1C(CC2=CC=CO2)=NC3=C(CC4=CC=CC=C4F)NC(C5=CC=CC(N)=C5F)=CN31
References1) Gaspar N, Walker JR, Zambito G, Marella-Panth K, Lowik C, Kirkland TA, Mezzanotte L. Evaluation of NanoLuc substrates for bioluminescence imaging of transferred cells in mice. J Photochem Photobiol B. 2021 Mar;216:112128. doi: 10.1016/j.jphotobiol.2021.112128. Epub 2021 Jan 26. PMID: 33529963.

2) Su Y, Walker JR, Park Y, Smith TP, Liu LX, Hall MP, Labanieh L, Hurst R, Wang DC, Encell LP, Kim N, Zhang F, Kay MA, Casey KM, Majzner RG, Cochran JR, Mackall CL, Kirkland TA, Lin MZ. Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals. Nat Methods. 2020 Aug;17(8):852-860. doi: 10.1038/s41592-020-0889-6. Epub 2020 Jul 13. PMID: 32661427.

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