Enzyme Inhibitors

KS15 View larger

KS15

AOB17572

CAS: 1033781-20-2

 

Chemical Name: (R,E)-3-(3-(1-(((4-Bromobenzyl)oxy)imino)ethyl)phenyl)-2-ethoxypropanoic acid

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$49.00

$49.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $22.05 Total: $2,205.00
150 $25.48 Total: $1,274.00
125 $29.89 Total: $747.25
110 $35.28 Total: $352.80
15 $41.65 Total: $208.25

Data sheet

Molecular FormulaC20H22BrNO4
Molecular Weight420.30
CAS Numbers1033781-20-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymKS15; KS 15; KS-15
IUPAC/Chemical Name(R,E)-3-(3-(1-(((4-Bromobenzyl)oxy)imino)ethyl)phenyl)-2-ethoxypropanoic acid
InChl KeyGWSVRVKPZVYTCS-VZMFNRANSA-N
InChl CodeInChI=1S/C20H22BrNO4/c1-3-25-19(20(23)24)12-16-5-4-6-17(11-16)14(2)22-26-13-15-7-9-18(21)10-8-15/h4-11,19H,3,12-13H2,1-2H3,(H,23,24)/b22-14+/t19-/m1/s1
SMILES CodeO=C(O)[C@H](OCC)CC1=CC=CC(/C(C)=N/OCC2=CC=C(Br)C=C2)=C1
References1) Jang J, Chung S, Choi Y, Lim HY, Son Y, Chun SK, Son GH, Kim K, Suh YG, Jung JW. The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55.

2) Zhu Z, Yang F, Chen P, Liu H, Cao W, Zhang K, Liu X, Zheng H. Emergence of novel Seneca Valley virus strains in China, 2017. Transbound Emerg Dis. 2017 Aug;64(4):1024-1029.

3) Chun SK, Chung S, Kim HD, Lee JH, Jang J, Kim J, Kim D, Son GH, Oh YJ, Suh YG, Lee CS, Kim K. A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells. Biochem Biophys Res Commun. 2015 Nov 13;467(2):441-6.

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Novel cryptochrome (CRY) inhibitor, enhancing E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex.

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