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Pathway Inhibitors
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Stafib-1
AOB5777
CAS No : 1688703-26-5
Chemical Name: 4-((2-((6-(Phenylcarbamoyl) naphthalen-2-yl)oxy) acetamido)methyl)-1,2-phenylene bis(dihydrogen phosphate)
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $22.05 | Total: $2,205.00 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 5 | $41.65 | Total: $208.25 |
Data sheet
| Molecular Formula | C26H24N2O11P2 |
| Molecular Weight | 602.42 |
| CAS Numbers | 1688703-26-5 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO and Water |
| Purity | 98% by HPLC |
| Synonym | Stafib-1; Stafib 1; Stafib1 |
| IUPAC/Chemical Name | 4-((2-((6-(Phenylcarbamoyl) naphthalen-2-yl)oxy) acetamido)methyl)-1,2-phenylene bis(dihydrogen phosphate) |
| InChl Key | SMUYYYBDKASIKY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C26H24N2O11P2/c29-25(27-15-17-6-11-23(38-40(31,32)33)24(12-17)39-41(34,35)36)16-37-22-10-9-18-13-20(8-7-19(18)14-22)26(30)28-21-4-2-1-3-5-21/h1-14H,15-16H2,(H,27,29)(H,28,30)(H2,31,32,33)(H2,34,35,36) |
| SMILES Code | O=C(NCC1=CC=C(OP(O)(O)=O)C(OP(O)(O)=O)=C1)COC2=CC=C3C=C(C(NC4=CC=CC=C4)=O)C=CC3=C2 |
| References | 1) Elumalai N, Natarajan K, Berg T. Halogen-substituted catechol bisphosphates are potent and selective inhibitors of the transcription factor STAT5b. Bioorg Med Chem. 2017 Jul 15;25(14):3871-3882. 2) Elumalai N, Berg A, Rubner S, Blechschmidt L, Song C, Natarajan K, Matysik J, Berg T. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7(1):819. |
More info
The first small molecule inhibitor of the STAT5b SH2 domain (Ki =44 nM) with more than 50-fold selectivity over STAT5a.
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