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G150
AOB13368
CAS: 2369751-30-2
Chemical Name: 1-(9-(6-Aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $16.88 | Total: $1,687.50 |
| 1 | 50 | $19.50 | Total: $975.00 |
| 1 | 25 | $22.88 | Total: $571.88 |
| 1 | 10 | $27.00 | Total: $270.00 |
| 1 | 5 | $31.88 | Total: $159.38 |
Data sheet
| Molecular Formula | C18H16Cl2N4O2 |
| Molecular Weight | 391.25 |
| CAS Numbers | 2369751-30-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 1-(9-(6-Aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one |
| InChl Key | VVUOUIPXYFIWLE-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H16Cl2N4O2/c19-12-5-10(9-1-2-14(21)22-6-9)16-11-7-24(15(26)8-25)4-3-13(11)23-18(16)17(12)20/h1-2,5-6,23,25H,3-4,7-8H2,(H2,21,22) |
| SMILES Code | NC1=CC=C(C2=C3C(NC4=C3CN(C(CO)=O)CC4)=C(Cl)C(Cl)=C2)C=N1 |
| References | Lama L, et al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21;10(1):2261 |
More info
Novel potent and highly selective human cGAS inhibitor for repression of dsDNA-triggered interferon expression ( IC50 of 10.2 nM and 25000 nM for h-cGAS and m-cGAS, respectively)
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