Pathway Inhibitors

JH-RE-06 View larger

JH-RE-06

AOB13138

CAS No: 1361227-90-8


Chemical Name: 8-Chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methylbutanoyl)-5-nitro-4(1H)-quinolinone

AOBIOUS launched this product in 2019

Citation (Publications used AOBIOUS products)

1) Mol Cell. 2021 Oct 7; 81(19): 4026–4040.e8.

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Molarity Calculation Cart®

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$21.00

$21.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $9.45 Total: $945.00
50 $10.92 Total: $546.00
25 $12.81 Total: $320.25
10 $15.12 Total: $151.20
5 $17.85 Total: $89.25

Data sheet

Molecular FormulaC20H16Cl3N3O4
Molecular Weight468.72
CAS Numbers1361227-90-8
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name8-chloro-2-((2,4-dichlorophenyl)amino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one
InChl KeyLRTXIQCBQIKIOH-UHFFFAOYSA-N
InChl CodeInChI=1S/C20H16Cl3N3O4/c1-9(2)7-15(27)17-19(28)16-14(26(29)30)6-4-11(22)18(16)25-20(17)24-13-5-3-10(21)8-12(13)23/h3-6,8-9H,7H2,1-2H3,(H2,24,25,28)
SMILES CodeClC1=C(NC(NC2=CC=C(Cl)C=C2Cl)=C(C(CC(C)C)=O)C3=O)C3=C([N+]([O-])=O)C=C1
References1) REV1-POLς Inhibition Enhances Cisplatin-Induced Cytotoxicity. Cancer Discov. 2019 Jun 14.

2) Wojtaszek JL, Chatterjee N, Najeeb J, Ramos A, Lee M, Bian K, Xue JY, Fenton BA, Park H, Li D, Hemann MT, Hong J, Walker GC, Zhou P. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. Cell. 2019 Jun 4.

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A novel inhibitor of mutagenic translesion synthesis (TLS), disrupting mutagenic TLS by preventing recruitment of mutagenic POL ζ, targets a nearly featureless surface of REV1 that interacts with the REV7 subunit of POL ζ, inducing REV1 dimerization to block the REV1-REV7 interaction.

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