Pathway Inhibitors

CYD19 View larger

CYD19

AOB11460

CAS: 2415281-52-4

Chemical Name: N-(2-Amino-4-fluorophenyl)-4-(((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)methyl)benzamide

AOBIOUS launched this product in 2021

CITATIONS - Publications That Use AOBIOUS Product

1) Oncogene volume 42pages2659–2672 (2023)

2) Biorxiv 2022

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HOW TO ORDER

$31.00

$31.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $13.95 Total: $1,395.00
150 $16.12 Total: $806.00
125 $18.91 Total: $472.75
110 $22.32 Total: $223.20
15 $26.35 Total: $131.75

Data sheet

Molecular FormulaC24H21FN8OS
Molecular Weight488.55
CAS Numbers2415281-52-4
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymCYD 19, CYD-19; Snail/HDAC-IN-1
IUPAC/Chemical NameN-(2-Amino-4-fluorophenyl)-4-(((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)methyl)benzamide
References1) Hong-Mei Li et al., A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer, Science Advances 22 Apr 2020: Vol. 6, no. 17, eaaw8500

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Novel potent CBP/p300-Snail interaction inhibitor, suppressing tumor growth and metastasis in wild-type p53-expressing cancer, forming a high-affinity interaction with the evolutionarily conserved arginine-174 pocket of Snail protein, reversing Snail-mediated epithelial-mesenchymal transition (EMT) and impairs EMT-associated tumor invasion and metastasis

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