Pathway Inhibitors

MRTX-EX185 View larger

MRTX-EX185

AOB16206

CAS 2621927-57-7

Chemical Name: 4-(4-((1R,5S)-3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynylnaphthalen-2-ol

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$59.00

$59.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $26.55 Total: $2,655.00
150 $30.68 Total: $1,534.00
125 $35.99 Total: $899.75
110 $42.48 Total: $424.80
15 $50.15 Total: $250.75

Data sheet

Molecular FormulaC33H33FN6O2
Molecular Weight564.67
CAS Numbers2621927-57-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name4-(4-((1R,5S)-3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-((tetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynylnaphthalen-2-ol
SMILES CodeOC1=CC(C2=C(F)C3=NC(OCC45CCCN4CCC5)=NC(N6C[C@@](N7)([H])CC[C@@]7([H])C6)=C3C=N2)=C8C(C#C)=CC=CC8=C1.O=CO
References1) Vasta JD, et, al. KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nat Chem Biol. 2022 Mar 21.

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Novel KRAS(G12D) inhibitor, binding to both the GDP state and the GTP state of KRAS(G12D) in a cell-free system, engaging KRAS mutants and drives antiproliferation, demonstrating time- and dose-dependent inhibition of the KRAS(G12D):CRAF(RBD) interaction

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