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PFI-2 Hydrochloride View larger

(R)-PFI-2 Hydrochloride

AOB37700

CAS: 1627607-87-7

 

Chemical Name: (R)-PFI-2 hydrochloride; 8-Fluoro-1,2,3,4-tetrahydro-isoquinoline-6-sulfonic acid [2-oxo-2-pyrrolidin-1-yl-1(R)-(3-trifluoromethyl-benzyl)-ethyl]-amide hydrochloride

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$15.00

$15.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $6.75 Total: $675.00
50 $7.80 Total: $390.00
25 $9.15 Total: $228.75
10 $10.80 Total: $108.00
5 $12.75 Total: $63.75

Data sheet

Molecular FormulaC23H25F4N3O3S • HCl
Molecular Weight536.0
CAS Numbers1627607-87-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name8-fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide, monohydrochloride
InChl KeyZADKZNVAJGEFLC-ZMBIFBSDSA-N
InChl CodeInChI=1S/C23H25F4N3O3S.ClH/c24-20-13-18(12-16-6-7-28-14-19(16)20)34(32,33)29-21(22(31)30-8-1-2-9-30)11-15-4-3-5-17(10-15)23(25,26)27;/h3-5,10,12-13,21,28-29H,1-2,6-9,11,14H2;1H/t21-;/m1./s1
SMILES CodeO=S(C1=CC(CCNC2)=C2C(F)=C1)(N[C@H](CC3=CC(C(F)(F)F)=CC=C3)C(N4CCCC4)=O)=O.Cl
References1) Couture, J.F., Collazo, E., Hauk, G., et al. Structural basis for the methylation site specificity of SET7/9. Nature Structural & Molecular Biology 13(2), 140-146 (2006).

2) Kurash, J.K., Lei, H., Shen, Q., et al. Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. Molecular Cell 29, 392-400 (2008).

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