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Y27632 2 HCl View larger

Y27632 2HCl

AOB3877

CAS No:129830-38-2

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$7.00

$7.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $3.15 Total: $315.00
150 $3.64 Total: $182.00
125 $4.27 Total: $106.75
110 $5.04 Total: $50.40
15 $5.95 Total: $29.75

Data sheet

Molecular FormulaC14H23Cl2N3O
Molecular Weight320.26
CAS Numbers129830-38-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymY27632; Y-27632; Y 27632; Y27632 HCl; Y27632 dihydrochloride
IUPAC/Chemical Name(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
InChl KeyIDDDVXIUIXWAGJ-LJDSMOQUSA-N
InChl CodeInChI=1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11-,12-;;/m1../s1
SMILES CodeO=C([C@H]1CC[C@H]([C@H](N)C)CC1)NC2=CC=NC=C2.[H]Cl.[H]Cl
References1) Yang CY, et al., Effects of Y27632 on aqueous humor outflow facility with changes in hydrodynamic pattern and morphology in human eyes. Invest Ophthalmol Vis Sci. 2013 Aug 28;54(8):5859-70. doi: 10.1167/iovs.12-10930. PubMed PMID: 23920374; PubMed Central PMCID: PMC3757907.

2) Gandham VD, et al., Effects of Y27632 on keratinocyte procurement and wound healing. Clin Exp Dermatol. 2013 Oct;38(7):782-6. doi: 10.1111/ced.12067. Epub 2013 May 16. PubMed PMID: 23675999; PubMed Central PMCID: PMC3748215.

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A selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.

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