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Purinergic Receptors

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NF449 sodium salt

AOB3045

CAS No: 627034-85-9; 389142-38-5 (free acid)

Chemical Name: 4,4',4'',4'''-[Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino))]tetrakis-1,3-benzenedisulfonic acid, octasodium salt

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $5.85 Total: $585.00
150 $6.76 Total: $338.00
125 $7.93 Total: $198.25
110 $9.36 Total: $93.60
15 $11.05 Total: $55.25

Data sheet

Molecular FormulaC41H24N6Na8O29S8
Molecular Weight1505.1
CAS Numbers627034-85-9
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityPBS (pH 7.2): 10 mg/ml
Purity98% by HPLC
SynonymNF449; NF 449; NF-449.
IUPAC/Chemical Name4,4',4'',4'''-[carbonylbis[imino-5,1,3-benzenetriylbis(carbonylimino)]]tetrakis-1,3-benzenedisulfonic acid, octasodium salt
InChl KeyKCBZSNWCUJBMHF-UHFFFAOYSA-F
InChl Code InChI=1S/C41H32N6O29S8.8Na/c48-37(44-29-5-1-25(77(53,54)55)15-33(29)81(65,66)67)19-9-20(38(49)45-30-6-2-26(78(56,57)58)16-34(30)82(68,69)70)12-23(11-19)42-41(52)43-24-13-21(39(50)46-31-7-3-27(79(59,60)61)17-35(31)83(71,72)73)10-22(14-24)40(51)47-32-8-4-28(80(62,63)64)18-36(32)84(74,75)76;;;;;;;;/h1-18H,(H,44,48)(H,45,49)(H,46,50)(H,47,51)(H2,42,43,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76);;;;;;;;/q;8*+1/p-8
SMILES CodeO=C(NC1=CC(C(NC2=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C=C2)=O)=CC(C(NC3=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C=C3)=O)=C1)NC4=CC(C(NC5=CC=C(S([O-])(=O)=O)C=C5S([O-])(=O)=O)=O)=CC(C(NC6=CC=C(S([O-])(=O)=O)C=C6S([O-])(=O)=O)=O)=C4.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
References1) Kassack, M.U., Braun, K., Ganso, M., et al. Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist. Eur. J. Med. Chem. 39(4), 345-357 (2004).

2) El-Ajouz, S., Ray, D., Allsopp, R.C., et al. Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: Contribution of basic amino acids in the cysteine-rich loop. Br. J. Pharmacol. 165(2), 390-400 (2012).

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Potent and selective antagonist of P2X1