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> Proteins and Antibodies>Antibodies and Kits>RABBIT MONOCLONAL>Rabbit anti-human PD-L1 Monoclonal Antibody Clone 8C6

RABBIT MONOCLONAL

Rabbit anti-human PD-L1 Monoclonal Antibody Clone 8C6 View larger

Rabbit anti-human PD-L1 Monoclonal Antibody Clone 8C6

AP35774M8C6

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HOW TO ORDER

$245.00

$245.00 per 100 µl

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DESCRIPTION

Species Reactivity

Human PD-L1

Immunogen

recombinant human PD-L1 extracellular domain

Purity

> 95%  by SDS-PAGE

Formulation

PBS with 0.09% sodium azide, 50%  glycerol, pH7.4

Size

100µl (concentration 1mg/mL)

APPLICATION

ELISA

FC

1:100 - 1:1000

Western Blot

1:1000 - 1:3000

Research Use Only

PREPARATION AND STORAGE

Preparation 

Monoclonal antibody is produced by immunizing rabbit with recombinant human PD-L1 extracellular domain and purified using protein A resin.

Storage

This antibody is shipped at 4 o C. This product is stable for 12 months from date of receipt when stored at -20 o C to -70 o C. Avoid freeze/thaw cycles.

BACKGROUND

Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and nonhematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1- PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PDL1 has become an important biomarker and immunotherapy target for many types of malignancies