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Rabbit anti-human HER2 Monoclonal Antibody Clone 1B11
AP35772M1B11
Molarity Calculation Cart®
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DESCRIPTION | |
Species Reactivity | Human HER2 |
Immunogen | Recombinant human HER2 extracellular domain |
Purity | > 95% by SDS-PAGE |
Formulation | PBS with 0.09% sodium azide , 50% glycerol, pH 7.4 |
Size | 50µl |
APPLICATION | |
ELISA | 1:1000 |
Western Blot | 1:500 - 1:1000 |
Immunohistochemistry | |
Research Use Only | |
PREPARATION AND STORAGE | |
Preparation | Monoclonal antibody is produced by immunizing rabbit with recombinant human HER2 extracellular domain and purified using protein A resin. |
Storage | This antibody is shipped at 4 oC. This product is stable for 12 months from date of receipt when stored at -20oC to -70oC. Avoid freeze/thaw cycles. |
BACKGROUND
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) tyrosine kinase family. Heterodimer of HER2 with other HER family members stimulate cell proliferation and suppress cell apoptosis via a range of downstream signaling pathways. Amplification or over-expression of HER2 has been demonstrated to play a critical role in the development and progression of many aggresive types of tumors. Recently, the protein has become a key biomarker and leading therapeutic target of breast cancer, lung cancer,and etc. |