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> Pathway Inhibitors>Transporter Inhibitors>Nisoxetine hydrochloride

Transporter Inhibitors

Nisoxetine hydrochloride View larger

Nisoxetine hydrochloride

AOB31775

CAS No: 57754-86-6

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$13.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $11.05 Total: $55.25
110 $9.36 Total: $93.60
125 $7.93 Total: $198.25
150 $6.76 Total: $338.00
1100 $5.85 Total: $585.00

Data sheet

Molecular FormulaC17H21NO2.HCl
Molecular Weight307.82
CAS Numbers57754-86-6
Storage Condition+4C
Solubility100 mM in water
Purity 99% (HPLC)
IUPAC/Chemical Nameγ-(2-methoxyphenoxy)-N-methyl-benzenepropanamine, monohydrochloride
InChl KeyLCEURBZEQJZUPV-UHFFFAOYSA-N
InChl CodeInChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H
SMILES CodeCNCCC(C1=CC=CC=C1)OC2=C(OC)C=CC=C2.Cl
References1) Torres, G.E., Gainetdinov, R.R., and Caron, M.G. Plasma membrane monoamine transporters: Structure, regulation and function. Nat. Rev. Neurosci. 4(1), 13-25 (2003).

2) Tyler, T.D., and Tessel, R.E. Amphetamine’s locomotor-stimulant and noreprinephrine-releasing effects: Evidence for selective antagonism by nisoxetine. Psychopharmacology (Berl) 64(3), 291-296 (1979).

More info

Potent and selective inhibitor of the norepinephrine transporter

Nisoxetine hydrochloride is a selective norepinephrine reuptake inhibitor (NRI). It is primarily used in research rather than as an approved therapeutic drug.

Key Pharmacological Actions

1. Selective inhibition of norepinephrine reuptake

  • Nisoxetine blocks the norepinephrine transporter (NET) on presynaptic neurons.

  • This increases norepinephrine levels in the synaptic cleft.

  • Enhances noradrenergic signaling in the brain and peripheral nervous system.

2. High selectivity

  • It has minimal effect on serotonin (SERT) and dopamine (DAT) reuptake systems compared to its strong action on NET.

  • Because of this selectivity, it is often used in experiments to differentiate NET function from other monoamine systems.

3. Research applications
Nisoxetine is commonly used to:

  • Study NET density and distribution via radiolabeled derivatives.

  • Investigate noradrenergic involvement in mood regulation, attention, pain perception, and autonomic function.

  • Characterize pharmacodynamics of antidepressants that target norepinephrine.

4. Not approved for clinical use

  • Despite being developed as an antidepressant candidate, it was never marketed.

  • Its role is largely preclinical and experimental.

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