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Ubiquitin-Activating Enzyme
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MLN7243 (TAK-243)
AOB87172
CAS No:1450833-55-2
Chemical Name: TAK-243; [(1R,2R,3S,4R)-2,3-dihydroxy-4-[[2-[3-[(trifluoromethyl)thio]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]sulfamic acid methyl ester
AOBIOUS launched this product in 2015
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $15.08 | Total: $1,507.50 |
| 1 | 50 | $17.42 | Total: $871.00 |
| 1 | 25 | $20.44 | Total: $510.88 |
| 1 | 10 | $24.12 | Total: $241.20 |
| 1 | 5 | $28.48 | Total: $142.38 |
Data sheet
| Molecular Formula | C19H20F3N5O5S2 |
| Molecular Weight | 519.5 |
| CAS Numbers | 1450833-55-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | methyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate |
| InChl Key | PUMGWJMQPGYZFC-IDCJVQTKSA-N |
| InChl Code | InChI=1S/C19H20F3N5O5S2/c1-32-34(30,31)26-14-8-13(17(28)18(14)29)24-15-5-6-23-16-9-12(25-27(15)16)10-3-2-4-11(7-10)33-19(20,21)22/h2-7,9,13-14,17-18,24,26,28-29H,8H2,1H3/t13-,14+,17+,18-/m1/s1 |
| SMILES Code | COS(=O)(=O)N[C@H]1C[C@H]([C@@H]([C@@H]1O)O)NC2=CC=NC3=CC(=NN23)C4=CC(=CC=C4)SC(F)(F)F |
| References | 1) Preparation of ubiquitin-activating enzyme inhibitor and use alone and in combination with other chemotherapeutic agents for treatment of cancer by Bence, Neil etc from PCT Int. Appl. (2016), WO 2016069392 A1 20160506. 2) Preparation of ubiquitin-activating enzyme inhibitor and use in combination with radiation for treatment of cancer by Bence, Neil etc from PCT Int. Appl. (2016), WO 2016069393 A1 20160506. 3) Preparation of pyrazolopyrimidinyl compounds as inhibitors of ubiquitin-activating enzyme by Afroze, Roushan etc from PCT Int. Appl. (2013), WO 2013123169 A1 20130822 |
More info
The first-in-class selective inhibitor of ubiquitin-activating enzymes (UAE, also known as E1 enzymes)
