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> Pathway Inhibitors>Enzyme Inhibitors>Ubiquitin-Activating Enzyme>MLN7243 (TAK-243)

Ubiquitin-Activating Enzyme

MLN7243 View larger

MLN7243 (TAK-243)

AOB87172

CAS No:1450833-55-2

Chemical Name: TAK-243; [(1R,2R,3S,4R)-2,3-dihydroxy-4-[[2-[3-[(trifluoromethyl)thio]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]amino]cyclopentyl]sulfamic acid methyl ester

AOBIOUS launched this product in 2015

CITATIONS - Publications That Use AOBIOUS Product

1) Dev Cell. 2018 Jan 8; 44(1): 97–112.e7

2) Autophagy Volume 18, 2022 - Issue 8

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$33.50

$33.50 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $28.48 Total: $142.38
110 $24.12 Total: $241.20
125 $20.44 Total: $510.88
150 $17.42 Total: $871.00
1100 $15.08 Total: $1,507.50

Data sheet

Molecular FormulaC19H20F3N5O5S2
Molecular Weight519.5
CAS Numbers1450833-55-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Namemethyl ((1S,2R,3S,4R)-2,3-dihydroxy-4-((2-(3-((trifluoromethyl)thio)phenyl)pyrazolo[1,5-a]pyrimidin-7-yl)amino)cyclopentyl)sulfamate
InChl KeyPUMGWJMQPGYZFC-IDCJVQTKSA-N
InChl CodeInChI=1S/C19H20F3N5O5S2/c1-32-34(30,31)26-14-8-13(17(28)18(14)29)24-15-5-6-23-16-9-12(25-27(15)16)10-3-2-4-11(7-10)33-19(20,21)22/h2-7,9,13-14,17-18,24,26,28-29H,8H2,1H3/t13-,14+,17+,18-/m1/s1
SMILES CodeCOS(=O)(=O)N[C@H]1C[C@H]([C@@H]([C@@H]1O)O)NC2=CC=NC3=CC(=NN23)C4=CC(=CC=C4)SC(F)(F)F
References1) Preparation of ubiquitin-​activating enzyme inhibitor and use alone and in combination with other chemotherapeutic agents for treatment of cancer by Bence, Neil etc from PCT Int. Appl. (2016), WO 2016069392 A1 20160506.

2) Preparation of ubiquitin-​activating enzyme inhibitor and use in combination with radiation for treatment of cancer by Bence, Neil etc from PCT Int. Appl. (2016), WO 2016069393 A1 20160506.

3) Preparation of pyrazolopyrimidinyl compounds as inhibitors of ubiquitin-​activating enzyme by Afroze, Roushan etc from PCT Int. Appl. (2013), WO 2013123169 A1 20130822

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The first-in-class selective inhibitor of ubiquitin-activating enzymes (UAE, also known as E1 enzymes)

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