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AEM1
AOB5036
CAS No: 1030123-90-0
Chemical Name: N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $6.75 | Total: $675.00 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 5 | $12.75 | Total: $63.75 |
Data sheet
| Molecular Formula | C20H14FN3O2S |
| Molecular Weight | 379.41 |
| CAS Numbers | 1030123-90-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine |
| InChl Key | QGYLTGSHWIGJJD-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24) |
| SMILES Code | FC(C=C1)=CC=C1C2=CSC3=C2C(NCC4=CC=C(OCO5)C5=C4)=NC=N3 |
| References | 1) DeNicola, G.M., Karreth, F.A., Humpton, T.J., et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475(7354), 106-109 (2011). 2) Bollong, M.J., Yun, H., Sherwood, L., et al. A small molecule inhibits deregulated NRF2 transcriptional activity in cancer. ACS Chemical Biology 10(10), 2193-2198 (2015). |
More info
Novel inhibitor of deregulated NRF2 transcriptional activity in cancer, broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibiting the growth of A549 cells in vitro and in vivo.
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