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View larger (R)-SKBG-1
AOB10794
CAS: 2955634-67-8
Chemical Name: (R)-4-(2-Chloroacetyl)-N-(4-methoxybenzyl)-1-((4-methoxyphenyl)sulfonyl)piperazine-2-carboxamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | 1 mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $58.65 | Total: $293.25 |
| 1 | 10 | $49.68 | Total: $496.80 |
| 1 | 25 | $42.09 | Total: $1,052.25 |
| 1 | 50 | $35.88 | Total: $1,794.00 |
| 1 | 100 | $31.05 | Total: $3,105.00 |
Data sheet
| Molecular Formula | C22H26ClN3O6S |
| Molecular Weight | 495.98 |
| CAS Numbers | 2955634-67-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO and Water |
| Purity | 98% by HPLC |
| Synonym | (R)-SKBG-1; (R)-SKBG 1; (R)-SKBG1 |
| IUPAC/Chemical Name | (R)-4-(2-chloroacetyl)-N-(4-methoxybenzyl)-1-((4-methoxyphenyl)sulfonyl)piperazine-2-carboxamide |
| InChl Key | SXQZEMXQTRNLRZ-HXUWFJFHSA-N |
| InChl Code | InChI=1S/C22H26ClN3O6S/c1-31-17-5-3-16(4-6-17)14-24-22(28)20-15-25(21(27)13-23)11-12-26(20)33(29,30)19-9-7-18(32-2)8-10-19/h3-10,20H,11-15H2,1-2H3,(H,24,28)/t20-/m1/s1 |
| SMILES Code | O=C([C@@H]1N(S(=O)(C2=CC=C(OC)C=C2)=O)CCN(C(CCl)=O)C1)NCC3=CC=C(OC)C=C3 |
| References | 1) Kathman SG, Koo SJ, Lindsey GL, Her HL, Blue SM, Li H, Jaensch S, Remsberg JR, Ahn K, Yeo GW, Ghosh B, Cravatt BF. Remodeling oncogenic transcriptomes by small molecules targeting NONO. Nat Chem Biol. 2023 Mar 2. doi: 10.1038/s41589-023-01270-0. Epub ahead of print. PMID: 36864190. |
More info
Novel covalent NONO ligand, engaging C145 of the RNA-binding protein NONO, rapidly and stereoselectively decreasing the expression of transcripts encoding the androgen receptor and its splice variants in prostate cancer cells
