Cancer Research

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(R)-SKBG-1

AOB10794

CAS: 2955634-67-8

 

Chemical Name: (R)-4-(2-Chloroacetyl)-N-(4-methoxybenzyl)-1-((4-methoxyphenyl)sulfonyl)piperazine-2-carboxamide

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$69.00

$69.00 per 1 mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity1 mgUnit Price ($/mg or $/Unit)Final Price
1100 $31.05 Total: $3,105.00
150 $35.88 Total: $1,794.00
125 $42.09 Total: $1,052.25
110 $49.68 Total: $496.80
15 $58.65 Total: $293.25

Data sheet

Molecular FormulaC22H26ClN3O6S
Molecular Weight495.98
CAS Numbers2955634-67-8
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Water
Purity98% by HPLC
Synonym(R)-SKBG-1; (R)-SKBG 1; (R)-SKBG1
IUPAC/Chemical Name(R)-4-(2-chloroacetyl)-N-(4-methoxybenzyl)-1-((4-methoxyphenyl)sulfonyl)piperazine-2-carboxamide
InChl KeySXQZEMXQTRNLRZ-HXUWFJFHSA-N
InChl CodeInChI=1S/C22H26ClN3O6S/c1-31-17-5-3-16(4-6-17)14-24-22(28)20-15-25(21(27)13-23)11-12-26(20)33(29,30)19-9-7-18(32-2)8-10-19/h3-10,20H,11-15H2,1-2H3,(H,24,28)/t20-/m1/s1
SMILES CodeO=C([C@@H]1N(S(=O)(C2=CC=C(OC)C=C2)=O)CCN(C(CCl)=O)C1)NCC3=CC=C(OC)C=C3
References1) Kathman SG, Koo SJ, Lindsey GL, Her HL, Blue SM, Li H, Jaensch S, Remsberg JR, Ahn K, Yeo GW, Ghosh B, Cravatt BF. Remodeling oncogenic transcriptomes by small molecules targeting NONO. Nat Chem Biol. 2023 Mar 2. doi: 10.1038/s41589-023-01270-0. Epub ahead of print. PMID: 36864190.

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Novel covalent NONO ligand, engaging C145 of the RNA-binding protein NONO, rapidly and stereoselectively decreasing the expression of transcripts encoding the androgen receptor and its splice variants in prostate cancer cells

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