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View larger ONC206
AOB14466B
CAS: 1638178-87-6
Chemical Name: ONC-206; 11-Benzyl-7-[(2,4-difluorophenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one
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Data sheet
| Molecular Formula | C23H22F2N4O |
| Molecular Weight | 408.45 |
| CAS Numbers | 1638178-87-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| Synonym | ONC206; ONC-206; ONC 206. |
| IUPAC/Chemical Name | 7-benzyl-4-(2,4-difluorobenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one |
| InChl Key | ITMGVSSHWMTJRR-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C23H22F2N4O/c24-18-7-6-17(20(25)12-18)14-29-22(30)19-15-27(13-16-4-2-1-3-5-16)10-8-21(19)28-11-9-26-23(28)29/h1-7,12H,8-11,13-15H2 |
| SMILES Code | FC1=CC(F)=CC=C1CN2C(C(C3)=C(N4CCN=C42)CCN3CC5=CC=CC=C5)=O |
| References | 1) Ishida CT, et al. Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma. Clin Cancer Res. 2018 Nov 1;24(21):5392-5406. doi: 10.1158/1078-0432.CCR-18-1040. Epub 2018 Jul 23. PubMed PMID: 30037819; PubMed Central PMCID: PMC6214769. 2) Wagner J, et al. Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Cell Cycle. 2017 Oct 2;16(19):1790-1799. doi: 10.1080/15384101.2017.1325046. Epub 2017 May 10. PubMed PMID: 28489985; PubMed Central PMCID: PMC5628644. |
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Novel selective antagonist of the D2-like dopamine receptors (DRD2) with broad-spectrum anti-tumor activities
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