DA Receptors

ONC206 View larger

ONC206

AOB14466

CAS: 1638178-87-6

 

Chemical Name: ONC-206; 11-Benzyl-7-[(2,4-difluorophenyl)methyl]-2,5,7,11-tetrazatricyclo[7.4.0.02,6]trideca-1(9),5-dien-8-one

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$25.00

$25.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $11.25 Total: $1,125.00
150 $13.00 Total: $650.00
125 $15.25 Total: $381.25
110 $18.00 Total: $180.00
15 $21.25 Total: $106.25

Data sheet

Molecular FormulaC23H22F2N4O
Molecular Weight408.45
CAS Numbers1638178-87-6
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Alcohol
Purity98% by HPLC
SynonymONC206; ONC-206; ONC 206.
IUPAC/Chemical Name7-benzyl-4-(2,4-difluorobenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
InChl KeyITMGVSSHWMTJRR-UHFFFAOYSA-N
InChl CodeInChI=1S/C23H22F2N4O/c24-18-7-6-17(20(25)12-18)14-29-22(30)19-15-27(13-16-4-2-1-3-5-16)10-8-21(19)28-11-9-26-23(28)29/h1-7,12H,8-11,13-15H2
SMILES CodeFC1=CC(F)=CC=C1CN2C(C(C3)=C(N4CCN=C42)CCN3CC5=CC=CC=C5)=O
References1) Ishida CT, et al. Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma. Clin Cancer Res. 2018 Nov 1;24(21):5392-5406. doi: 10.1158/1078-0432.CCR-18-1040. Epub 2018 Jul 23. PubMed PMID: 30037819; PubMed Central PMCID: PMC6214769.

2) Wagner J, et al. Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212. Cell Cycle. 2017 Oct 2;16(19):1790-1799. doi: 10.1080/15384101.2017.1325046. Epub 2017 May 10. PubMed PMID: 28489985; PubMed Central PMCID: PMC5628644.

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