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Numidargistat (CB-1158)
AOB33256
CAS: 2095732-06-0
Chemical Name: (3R,4S)-1-(L-Alanyl)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $22.05 | Total: $2,205.00 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 5 | $41.65 | Total: $208.25 |
Data sheet
| Molecular Formula | C11H22BN3O5 |
| Molecular Weight | 287.12 |
| CAS Numbers | 2095732-06-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | CB-1158 B; CB1158 B; CB 1158 B; INCB01158 B, INCB 01158 B, INCB-01158 B, Numidargistat |
| IUPAC/Chemical Name | (3R,4S)-1-(L-alanyl)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid |
| InChl Key | ZZJLMZYUGLJBSO-LAEOZQHASA-N |
| InChl Code | InChI=1S/C11H22BN3O5/c1-7(13)9(16)15-5-8(3-2-4-12(19)20)11(14,6-15)10(17)18/h7-8,19-20H,2-6,13-14H2,1H3,(H,17,18)/t7-,8-,11-/m0/s1 |
| SMILES Code | O=C([C@]1(N)CN(C([C@H](C)N)=O)C[C@@H]1CCCB(O)O)O |
| References | Steggerda SM, Bennett MK, Chen J, Emberley E, Huang T, Janes JR, Li W, MacKinnon AL, Makkouk A, Marguier G, Murray PJ, Neou S, Pan A, Parlati F, Rodriguez MLM, Van de Velde LA, Wang T, Works M, Zhang J, Zhang W, Gross MI. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101 |
More info
Novel potent and selective inhibitor of human arginase I, blocking myeloid cell-mediated immune suppression in the tumor microenvironment
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