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> Pathway Inhibitors>Enzyme Inhibitors>Numidargistat (CB-1158)

Enzyme Inhibitors

CB-1158 View larger

Numidargistat (CB-1158)

AOB33256

CAS: 2095732-06-0

 

Chemical Name: (3R,4S)-1-(L-Alanyl)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid

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$49.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $41.65 Total: $208.25
110 $35.28 Total: $352.80
125 $29.89 Total: $747.25
150 $25.48 Total: $1,274.00
1100 $22.05 Total: $2,205.00

Data sheet

Molecular FormulaC11H22BN3O5
Molecular Weight287.12
CAS Numbers2095732-06-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymCB-1158 B; CB1158 B; CB 1158 B; INCB01158 B, INCB 01158 B, INCB-01158 B, Numidargistat
IUPAC/Chemical Name(3R,4S)-1-(L-alanyl)-3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid
InChl KeyZZJLMZYUGLJBSO-LAEOZQHASA-N
InChl CodeInChI=1S/C11H22BN3O5/c1-7(13)9(16)15-5-8(3-2-4-12(19)20)11(14,6-15)10(17)18/h7-8,19-20H,2-6,13-14H2,1H3,(H,17,18)/t7-,8-,11-/m0/s1
SMILES CodeO=C([C@]1(N)CN(C([C@H](C)N)=O)C[C@@H]1CCCB(O)O)O
References Steggerda SM, Bennett MK, Chen J, Emberley E, Huang T, Janes JR, Li W, MacKinnon AL, Makkouk A, Marguier G, Murray PJ, Neou S, Pan A, Parlati F, Rodriguez MLM, Van de Velde LA, Wang T, Works M, Zhang J, Zhang W, Gross MI. Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment. J Immunother Cancer. 2017 Dec 19;5(1):101

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Novel potent and selective inhibitor of human arginase I, blocking myeloid cell-mediated immune suppression in the tumor microenvironment

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