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SHMT-IN-2
AOB31454
CAS: 2102681-49-0
Chemical Name: Serine hydroxymethyltranferase inhibitor 2; 6-Amino-4-isopropyl-3-methyl-4-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $12.15 | Total: $1,215.00 |
| 1 | 50 | $14.04 | Total: $702.00 |
| 1 | 25 | $16.47 | Total: $411.75 |
| 1 | 10 | $19.44 | Total: $194.40 |
| 1 | 5 | $22.95 | Total: $114.75 |
Data sheet
| Molecular Formula | C22H24F3N5O |
| Molecular Weight | 431.46 |
| CAS Numbers | 2102681-49-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | SHMT-IN-2, Serine hydroxymethyltranferase inhibitor 2 |
| IUPAC/Chemical Name | 6-Amino-4-isopropyl-3-methyl-4-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile |
| InChl Key | NOKJZHRLDAOFCV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C22H24F3N5O/c1-12(2)21(17(11-26)19(27)31-20-18(21)13(3)28-29-20)14-8-15(22(23,24)25)10-16(9-14)30-6-4-5-7-30/h8-10,12H,4-7,27H2,1-3H3,(H,28,29) |
| SMILES Code | N#CC(C1(C(C)C)C2=CC(C(F)(F)F)=CC(N3CCCC3)=C2)=C(N)OC4=C1C(C)=NN4 |
| References | Gregory S et al., Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma, PNAS October 24, 2017 114 (43) 11404-11409; first published October 9, 2017 https://doi.org/10.1073/pnas.1706617114 |
More info
Novel serine hydroxymethyltransferase (SHMT) inhibitor, potently inhibiting both human SHMT1/2.
SHMT-IN-2 is an analog of SHIN2 (AOB11286)
