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> Pathway Inhibitors>Enzyme Inhibitors> SHP099 Hydrochloride

Enzyme Inhibitors

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SHP099 Hydrochloride

AOB37724

CAS: 1801747-11-4

 

Chemical Name: 6-(4-Amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine hydrochloride

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$11.00

$11.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $9.35 Total: $46.75
110 $7.92 Total: $79.20
125 $6.71 Total: $167.75
150 $5.72 Total: $286.00
1100 $4.95 Total: $495.00

Data sheet

Molecular FormulaC16H20Cl3N5
Molecular Weight388.72
CAS Numbers1801747-11-4
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine hydrochloride
InChl Key KHQHYRFUYAXWOQ-UHFFFAOYSA-N
InChl CodeInChI=1S/C16H19Cl2N5.ClH/c1-16(20)5-7-23(8-6-16)12-9-21-14(15(19)22-12)10-3-2-4-11(17)13(10)18;/h2-4,9H,5-8,20H2,1H3,(H2,19,22);1H
SMILES CodeNC1=NC(N2CCC(C)(N)CC2)=CN=C1C3=CC=CC(Cl)=C3Cl.[H]Cl
References1) LaRochelle JR, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, LaMarche MJ, Chopra R, Acker MG, Blacklow SC. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun. 2018 Oct 30;9(1):4508.

2) Pádua RAP, Sun Y, Marko I, Pitsawong W, Stiller JB, Otten R, Kern D. Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2. Nat Commun. 2018 Oct 30;9(1):4507

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Novel potent, selective, orally bioavailable, and efficacious SHP2 inhibitor

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