Quantity | = | Concentration | x | Volume | x | Molecular Weight |
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AOB6623
CAS No: 1599432-08-2
Chemical Name: (2E)-3-(4-Bromophenyl)-1-(4-(4-methoxybenzoyl)-1-piperazinyl)-2-propen-1-one,
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Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
---|---|---|---|
1 | 100 | $7.65 | Total: $765.00 |
1 | 50 | $8.84 | Total: $442.00 |
1 | 25 | $10.37 | Total: $259.25 |
1 | 10 | $12.24 | Total: $122.40 |
1 | 5 | $14.45 | Total: $72.25 |
Molecular Formula | C21H21BrN2O3 |
Molecular Weight | 429.31 |
CAS Numbers | 1599432-08-2 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO 10 mg/mL |
Purity | 98% by HPLC |
A high-affinity, potent and selective EBI2 (GPR183) antagonist (IC50 = 16 nM against 10 nM 7α,25-OHC for binding human EBI2) that inhibits 7α,25-OHC-induced GTPγS binding (IC50 = 8.5 and 7.0 nM, respectively, against 0.33 and 0.1 nM OHC; human EBI2-expressing CHO membrane), calcium mobilization (IC50 = 11 and 15 nM using human or mouse EBI2-transfected cells, respectively), and chemotaxis (IC50 = 0.3 nM against 20 nM OHC-induced U937 migration). NBIR189 displays no inhibitory potency against 5HT2A, muscarinic acetylcholine receptor M2, adrenoreceptor α1A, nor significant affintiy toward 18 other GPCRs/transporters/enzyme