G Protein-Coupled Receptor Ligands

DIM-C-pPhCO2Me View larger

NIBR189

AOB6623

CAS No: 1599432-08-2  

Chemical Name: (2E)-3-(4-Bromophenyl)-1-(4-(4-methoxybenzoyl)-1-piperazinyl)-2-propen-1-one,

More details

Molarity Calculation Cart®

HOW TO ORDER

$17.00

$17.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $7.65 Total: $765.00
150 $8.84 Total: $442.00
125 $10.37 Total: $259.25
110 $12.24 Total: $122.40
15 $14.45 Total: $72.25

Data sheet

Molecular FormulaC21H21BrN2O3
Molecular Weight429.31
CAS Numbers1599432-08-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO 10 mg/mL
Purity98% by HPLC

More info

A high-affinity, potent and selective EBI2 (GPR183) antagonist (IC50 = 16 nM against 10 nM 7α,25-OHC for binding human EBI2) that inhibits 7α,25-OHC-induced GTPγS binding (IC50 = 8.5 and 7.0 nM, respectively, against 0.33 and 0.1 nM OHC; human EBI2-expressing CHO membrane), calcium mobilization (IC50 = 11 and 15 nM using human or mouse EBI2-transfected cells, respectively), and chemotaxis (IC50 = 0.3 nM against 20 nM OHC-induced U937 migration). NBIR189 displays no inhibitory potency against 5HT2A, muscarinic acetylcholine receptor M2, adrenoreceptor α1A, nor significant affintiy toward 18 other GPCRs/transporters/enzymes, and exhibits good pharmacokinetic properties and oral availability in mice (AUC = 3608 nmol h/L, Cmax = 835 nM, tmax = 1 h, F = 49%; 3 mg/kg p.o.). A useful tool for probing EBI2-mediated physiological functions and autoimmune disorders.

Customers who bought this product also bought: