Growth Factors Receptors

AZD-9291 (Mereletinib) Mesylate View larger

AZD-9291 (Mereletinib) Mesylate

AOB8379

CAS No: 1421373--1

 

Chemical Name: 

Osimertinib Mesylate; N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide Mesylate

More details

Molarity Calculation Cart®

HOW TO ORDER

$5.00

$5.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $2.25 Total: $225.00
150 $2.60 Total: $130.00
125 $3.05 Total: $76.25
110 $3.60 Total: $36.00
15 $4.25 Total: $21.25

Data sheet

Molecular FormulaC29H37N7O5S
Molecular Weight595.72
CAS Numbers1421373-66-1 (mesylate)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymAZD-9291; AZD 9291; AZD9291; AZD-9291 mesylate; Mereletinib; Mereletinib mesylate; Osimertinib mesylate. Brand name: Tagrisso.
IUPAC/Chemical NameN-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide mesylate
InChl KeyFUKSNUHSJBTCFJ-UHFFFAOYSA-N
InChl CodeInChI=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24;1-5(2,3)4/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)
SMILES CodeCN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2.OS(=O)(C)=O
References1) Zhang Z, Yang S, Wang Q. Impact of MET alterations on targeted therapy with EGFR-tyrosine kinase inhibitors for EGFR-mutant lung cancer. Biomark Res. 2019 Nov 21;7:27. doi: 10.1186/s40364-019-0179-6. eCollection 2019. Review. PubMed PMID: 31832192; PubMed Central PMCID: PMC6873421.

2) Shetty V, Babu S. Management of CNS metastases in patients with EGFR mutation-positive NSCLC. Indian J Cancer. 2019 Nov;56(Supplement):S31-S37. doi: 10.4103/ijc.IJC_455_19. Review. PubMed PMID: 31793440.

More info

Novel water-soluble potent irriversible EGFR inhibitor

Customers who bought this product also bought: