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Kinase Inhibitors
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UNC10112785
AOB13455
CAS: 748142-06-5
Chemical Name: N-(4-Isopropylphenyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $16.88 | Total: $1,687.50 |
| 1 | 50 | $19.50 | Total: $975.00 |
| 1 | 25 | $22.88 | Total: $571.88 |
| 1 | 10 | $27.00 | Total: $270.00 |
| 1 | 5 | $31.88 | Total: $159.38 |
Data sheet
| Molecular Formula | C19H18N6 |
| Molecular Weight | 330.40 |
| CAS Numbers | 748142-06-5 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | UNC10112785; UNC-10112785; UNC 10112785 |
| IUPAC/Chemical Name | N-(4-Isopropylphenyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine |
| InChl Key | UODXTGBFBIFREQ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H18N6/c1-13(2)14-5-7-15(8-6-14)23-19-20-11-9-17(24-19)16-12-22-25-18(16)4-3-10-21-25/h3-13H,1-2H3,(H,20,23,24) |
| SMILES Code | CC(C1=CC=C(NC2=NC=CC(C3=C4C=CC=NN4N=C3)=N2)C=C1)C |
More info
Novel potent inhibitor of CDK8, CDK19, and CDK9 with IC50 at 1.05, 2.67, and 19.9 nM, respectively, causing MYC loss through both transcriptional and posttranslational mechanisms, and suppressing PDAC anchorage-dependent and anchorage-independent growth, inducing the substantial loss of MYC protein in both two-dimensional (2D) and 3D cell cultures
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