Kinase Inhibitors

GDC0084 View larger

GDC0084

AOB87677

CAS No: 1382979-44-3

More details

Molarity Calculation Cart®

HOW TO ORDER

$15.00

$15.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $6.75 Total: $675.00
150 $7.80 Total: $390.00
125 $9.15 Total: $228.75
110 $10.80 Total: $108.00
15 $12.75 Total: $63.75

Data sheet

Molecular FormulaC18H22N8O2
Molecular Weight382.42
CAS Numbers1382979-44-3
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymRG7666; RG-7666; RG 7666; GDC-0084; GDC0084; GDC 0084; Paxalisib
IUPAC/Chemical Name5-(6,6-dimethyl-4-morpholino-8,9-dihydro-6H-[1,4]oxazino[4,3-e]purin-2-yl)pyrimidin-2-amine
InChl KeyLGWACEZVCMBSKW-UHFFFAOYSA-N
InChl CodeInChI=1S/C18H22N8O2/c1-18(2)16-22-12-14(25-3-6-27-7-4-25)23-13(11-9-20-17(19)21-10-11)24-15(12)26(16)5-8-28-18/h9-10H,3-8H2,1-2H3,(H2,19,20,21)
SMILES CodeNC1=NC=C(C2=NC(N3CCOCC3)=C4N=C(C(C)(C)OCC5)N5C4=N2)C=N1
References1) Salphati L, et al., Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma. Drug Metab Dispos. 2016 Dec;44(12):1881-1889. Epub 2016 Sep 16. PubMed PMID: 27638506.

More info

A potent, selective inhibitor of Class I PI3K and mTOR with good penetration across the blood-brain barrier.

Customers who bought this product also bought: