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Kinase Inhibitors

R406 View larger

R406

AOB87473

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$10.00

$10.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $8.50 Total: $42.50
110 $7.20 Total: $72.00
125 $6.10 Total: $152.50
150 $5.20 Total: $260.00
1100 $4.50 Total: $450.00

Data sheet

Molecular FormulaC22H23FN6O5
Molecular Weight470.45
CAS Numbers841290-80-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymR 406, R406, R-406, Tamatinib
IUPAC/Chemical Name6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one
InChl KeyNHHQJBCNYHBUSI-UHFFFAOYSA-N
InChl CodeInChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
SMILES CodeCOC1=C(OC)C=C(NC2=NC(NC3=NC(NC(C(C)(C)O4)=O)=C4C=C3)=C(F)C=N2)C=C1OC
References1) Matsubara, S., Li, G., Takeda, K., et al. Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. American Journal of Respiration and Critical Care Medicine 173(1), 56-63 (2006).

2) Matsubara, S., Koya, T., Takeda, K., et al. Syk activation in dendritic cells is essential for airway hyperresponsiveness and inflammation. Am. J. Respir. Cell Mol. Biol. 34(4), 426-433 (2006).

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