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T6167923
AOB5875
CAS: 1090528-71-4
AOBIOUS launched this product in 2015
CITATIONS - Publications That Use AOBIOUS Product
1) Cancer Research:Oct 12,2016
2) Clin Exp Allergy 48:1676 (2018)
3) University of Oxford (2017)
4) Microorganisms (2020) 8:1804
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $9.45 | Total: $945.00 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 5 | $17.85 | Total: $89.25 |
Data sheet
| Molecular Formula | C17H20BrN3O3S2 |
| Molecular Weight | 458.39 |
| CAS Numbers | 1090528-71-4 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | T6167923; T-6167923; T 6167923 |
| IUPAC/Chemical Name | 4-(3-Bromophenyl)sulfonyl-N-(1-thiophen-2-ylethyl)piperazine-1-carboxamide |
| InChl Key | PNTQVMBKHCOLQD-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H20BrN3O3S2/c1-13(16-6-3-11-25-16)19-17(22)20-7-9-21(10-8-20)26(23,24)15-5-2-4-14(18)12-15/h2-6,11-13H,7-10H2,1H3,(H,19,22) |
| SMILES Code | O=C(N1CCN(S(=O)(C2=CC=CC(Br)=C2)=O)CC1)NC(C3=CC=CS3)C |
| References | 1) Saqib U, Baig MS. Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy. SAR QSAR Environ Res. 2018 Apr;29(4):295-318. doi: 10.1080/1062936X.2018.1431308. Epub 2018 Feb 15. PubMed PMID: 29448819. 2) Olson MA, Lee MS, Kissner TL, Alam S, Waugh DS, Saikh KU. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Sci Rep. 2015 Sep 18;5:14246. doi: 10.1038/srep14246. PubMed PMID: 26381092; PubMed Central PMCID: PMC4585646. |
More info
Novel inhibitor of MyD88-dependent signaling pathways, disrupting MyD88 homodimeric formation, which is critical for its signaling function
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