Reporter of Gene Expression

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CycLuc1

AOB1117

CAS No: 1247879-16-8

AOBIOUS launched this product in 2014

CITATIONS - Publications That Use AOBIOUS Product

1) Journal Of Nature Communication 7:11856 (2016)

2) Cell Transplant 26(12): 1878 (2017)

3) Science 359:935 (2018)

4) ASN Neuro. 2018 Jan-Dec; 10

5) Front. Immunol., 08 January 2019

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Molarity Calculation Cart®

HOW TO ORDER

$11.00

$11.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $4.95 Total: $495.00
50 $5.72 Total: $286.00
25 $6.71 Total: $167.75
10 $7.92 Total: $79.20
5 $9.35 Total: $46.75

Data sheet

Molecular FormulaC13H11N3O2S2
Molecular Weight305.38
CAS Numbers1247879-16-8
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC

More info

The synthetic firefly luciferase substrate CycLuc1 offers brighter bioluminescence and improved imaging in mouse models at lower doses than the standard D-luciferin. Binds to luciferase with higher affinity and emits about 5.7-fold more light than aminoluciferin and 3.2-fold more light than D-luciferin. Its superior light output is maintained over a wide range (1-100 µM). Shown to readily cross the blood-brain barrier in mice and provides much improved noninvasive bioluminescence imaging (BLI) of the brain at a lower dose when compared to D-luciferin. Yields about 10-fold higher bioluminescent signal than D-luciferin when Luc2 luciferase-expressing 4T1 breast cancer cells are implanted into the mammary fat pads of BABL/c mice. A rapid (4-5 min), long-lasting, and the steady signal peak is observed following an i.v injection CycLuc1 in mice.



Please note that the water-soluble CycLuc1 is also available with catalog number: AOB6377.

Reference:

1) Reddy, G. R, et al. 2010. J. Am. Chem. Soc. 132, 13586.

2) Melanie S Evans, Joanna P Chaurette, Spencer T Adams Jr, Gadarla R Reddy, Miranda A Paley et al. 2014. Nature Methods. 11, 393.

http://www.nature.com/nmeth/journal/v11/n4/full/nmeth.2883.html?WT.ec_id=NMETH-201404

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