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GSK321
AOB5893
CAS: 1816331-63-1
Chemical Name: (R)-1-(4-Fluorobenzyl)-N-(3-((S)-1-hydroxyethyl)phenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $16.65 | Total: $1,665.00 |
| 1 | 50 | $19.24 | Total: $962.00 |
| 1 | 25 | $22.57 | Total: $564.25 |
| 1 | 10 | $26.64 | Total: $266.40 |
| 1 | 5 | $31.45 | Total: $157.25 |
Data sheet
| Molecular Formula | C28H28FN5O3 |
| Molecular Weight | 501.56 |
| CAS Numbers | 1816331-63-1 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | GSK321; GSK 321; GSK-321. |
| IUPAC/Chemical Name | (R)-1-(4-Fluorobenzyl)-N-(3-((S)-1-hydroxyethyl)phenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide |
| InChl Key | IVFDDVKCCBDPQZ-MSOLQXFVSA-N |
| InChl Code | InChI=1S/C28H28FN5O3/c1-17-14-33(28(37)24-7-4-12-30-24)16-23-25(27(36)31-22-6-3-5-20(13-22)18(2)35)32-34(26(17)23)15-19-8-10-21(29)11-9-19/h3-13,17-18,30,35H,14-16H2,1-2H3,(H,31,36)/t17-,18+/m1/s1 |
| SMILES Code | O=C(C1=NN(CC2=CC=C(F)C=C2)C3=C1CN(C(C4=CC=CN4)=O)C[C@H]3C)NC5=CC=CC([C@@H](O)C)=C5 |
| References | 1) Okoye-Okafor UC, et al., New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat Chem Biol. 2015 Nov;11(11):878-86. doi: 10.1038/nchembio.1930. Epub 2015 Oct 5. PubMed PMID: 26436839. |
More info
Highly potent inhibitor of mutant IDH1 enzymes, showing modest activity against WT IDH1 and exhibiting minimal to no inhibitory activity against IDH2 proteins in biochemical and functional assays
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