Propargyl Choline

Novel biosynthetic label for choline phospholipids synthesis and monitor in cell culture and whole organism.

REFERENCES:

1) Jao et al. Metabolic Labeling and direct imaging of choline phospholipids in vivo. PNAS 106 (36):15332 (2009).

2) Luo et al High-Resolution Optical Molecular Imaging of Changes in Choline Metalolism in Oral Neoplasia 1, Translational Oncology 6:33-41 (2013)

2) Caishun et al. Practical Labeling Methodology for Choline-derived Lipids and Applications in Live Cell Fluorescence Imaging. Photochemistry and Photobiology 90:686 (2014).

3) Jao et al. Biosynthetic Labeling and Two-Color Imaging of Phospholipids in Cells. Chem. Bio. Chem. 16:472 (2015).

4) Zhao et al. Surface labeling of enveloped virus with polymeric imidazole-capped quantum dots via the metabolic incorporation of phospholipids into host cells. J. Mater. Chem. B 4:2421 (2016).

5) Di Guilmi et al. Specific and spatial labeling of choline-containing teichoic acids in Streptococcus pneumoniae by click chemistry. Chem. Commun.10.1039/c7cc05646j (2017).