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View larger RU.521
AOB37877
CAS: 2262452-06-0
AOBIOUS launched this product in 2017
CITATIONS - Publications That Use AOBIOUS Product
2) Experimental and Therapeutic Medicine 4157-4164 (2019)
3) Sci Adv. 2020 May; 6(21): eaaz6717.
4) Nucleic Acids Res. 2022 Mar 21; 50(5): 2681–2699.
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $16.15 | Total: $80.75 |
| 1 | 10 | $13.68 | Total: $136.80 |
| 1 | 25 | $11.59 | Total: $289.75 |
| 1 | 50 | $9.88 | Total: $494.00 |
| 1 | 100 | $8.55 | Total: $855.00 |
Data sheet
| Molecular Formula | C19H12Cl2N4O3 |
| Molecular Weight | 415.23 |
| CAS Numbers | 2262452-06-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | 2 mg per ml (4.82 mM) in DMSO |
| Purity | 95% by UHPLC |
| IUPAC/Chemical Name | 3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one |
| InChl Key | IAWZUQAOMURCLV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H12Cl2N4O3/c1-8-13(16-9-4-2-3-5-10(9)18(27)28-16)17(26)25(24-8)19-22-12-7-6-11(20)14(21)15(12)23-19/h2-7,16,24H,1H3,(H,22,23) |
| SMILES Code | O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5 |
| References | 1) Vincent J. et al., 2017. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 28(1):750. 2) Zhou W. et al., 2018. Structure of the human cGAS-DNA complex reveals enhanced control of immune surveillance. Cell. 174(2):300-311. |
| PubChem ID | 135397653 |
More info
Novel potent and selective inhibitor of cGAS, inhibiting cGAS-mediated signaling, being active in murine bone marrow-derived macrophages
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