Pathway Inhibitors

RU.521 View larger

RU.521

AOB37877

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$19.00

$19.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $8.55 Total: $855.00
150 $9.88 Total: $494.00
125 $11.59 Total: $289.75
110 $13.68 Total: $136.80
15 $16.15 Total: $80.75

Data sheet

Molecular FormulaC19H12Cl2N4O3
Molecular Weight415.23
CAS Numbers2262452-06-0
Storage Condition0°C (short term), -20°C (long term), desiccated
Solubility2 mg per ml (4.82 mM) in DMSO
Purity95% by UHPLC
IUPAC/Chemical Name3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one
InChl KeyIAWZUQAOMURCLV-UHFFFAOYSA-N
InChl CodeInChI=1S/C19H12Cl2N4O3/c1-8-13(16-9-4-2-3-5-10(9)18(27)28-16)17(26)25(24-8)19-22-12-7-6-11(20)14(21)15(12)23-19/h2-7,16,24H,1H3,(H,22,23)
SMILES CodeO=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5
References1) Vincent J. et al., 2017. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 28(1):750.

2) Zhou W. et al., 2018. Structure of the human cGAS-DNA complex reveals enhanced control of immune surveillance. Cell. 174(2):300-311.
PubChem ID135397653

More info

Novel potent and selective inhibitor of cGAS, inhibiting cGAS-mediated signaling, being active in murine bone marrow-derived macrophages

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