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TIC10
AOB2892
CAS No: 1616632-77-9
Chemical Name: 7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $7.65 | Total: $765.00 |
| 1 | 50 | $8.84 | Total: $442.00 |
| 1 | 25 | $10.37 | Total: $259.25 |
| 1 | 10 | $12.24 | Total: $122.40 |
| 1 | 5 | $14.45 | Total: $72.25 |
Data sheet
| Molecular Formula | C24H26N4O |
| Molecular Weight | 386.49 |
| CAS Numbers | 1616632-77-9 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Stock Solution Guide | 5 mMol/1.93mg/1mL and 10 mMol/3.87mg/1mL Solvent |
| Purity | 98% by HPLC |
| Synonym | ONC201; ONC 201; ONC-201; NSC350625; NSC-350625; NSC 350625; TIC10; TIC 10; TIC-10; TRAIL inducing compound 10; imipridone |
| IUPAC/Chemical Name | 7-benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one |
| InChl Key | VLULRUCCHYVXOH-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C24H26N4O/c1-18-7-5-6-10-20(18)16-28-23(29)21-17-26(15-19-8-3-2-4-9-19)13-11-22(21)27-14-12-25-24(27)28/h2-10H,11-17H2,1H3 |
| SMILES Code | O=C1N(CC2=CC=CC=C2C)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4 |
| References | 1) Pruss M, et al. Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma. Br J Cancer. 2020 Apr;122(8):1146-1157. doi: 10.1038/s41416-020-0759-0. Epub 2020 Mar 2. PMID: 32115576; PMCID: PMC7156767.2: Jacques S, van der Sloot AM, C Huard C, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD, Tyers M. Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development. Genetics. 2020 Apr;214(4):1103-1120. doi: 10.1534/genetics.119.302851. Epub 2020 Feb 24. PMID: 32094149; PMCID: PMC7153937. |
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Potent, orally active, dual inhibitor of Akt and ERK, signaling foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects
