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> Pathway Inhibitors>Enzyme Inhibitors>iBET-BD1 dihydrochloride (GSK778)

Enzyme Inhibitors

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iBET-BD1 dihydrochloride (GSK778)

AOB11459

CAS: 2451862-42-1 (free base)

 

Chemical Name: GSK778 2HCl; 4-(2-(Methoxymethyl)-1-((R)-1-phenylethyl)-8-(((S)-pyrrolidin-3-yl)methoxy)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole dihydrochloride

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$119.00

$119.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $101.15 Total: $505.75
110 $85.68 Total: $856.80
125 $72.59 Total: $1,814.75
150 $61.88 Total: $3,094.00
1100 $53.55 Total: $5,355.00

Data sheet

Molecular FormulaC30H35Cl2N5O3
Molecular Weight584.5
CAS Numbers 2451862-42-1 (free base)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymGSK778 2HCl, iBETBD1
IUPAC/Chemical Name4-(2-(Methoxymethyl)-1-((R)-1-phenylethyl)-8-(((S)-pyrrolidin-3-yl)methoxy)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole dihydrochloride
SMILES CodeCC1=NOC(C)=C1C2=C(OC[C@@H]3CNCC3)C=C4C5=C(N=C(COC)N5[C@H](C)C6=CC=CC=C6)C=NC4=C2
References1) Omer Gilan et al., Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation, Science 24 Apr 2020:

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Novel potent and selective BD1 inhibior (IC50: BRD2 BD1: 75nM; BRD3 BD1 41nM; BRD4 BD1 41nM)

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