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DPM-1001
AOB33273
CAS No: 1471172-27-6
Chemical Name: Methyl (3β,7α)-3-((4-((pyridin-2-ylmethyl)amino)butyl)amino)-7-hydroxycholan-24-oate
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $35.55 | Total: $3,555.00 |
| 1 | 50 | $41.08 | Total: $2,054.00 |
| 1 | 25 | $48.19 | Total: $1,204.75 |
| 1 | 10 | $56.88 | Total: $568.80 |
| 1 | 5 | $67.15 | Total: $335.75 |
Data sheet
| Molecular Formula | C35H57N3O3 |
| Molecular Weight | 567.86 |
| CAS Numbers | 1471172-27-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 99% (HPLC) |
| Synonym | DPM-1001; DPM1001; DPM 1001 |
| IUPAC/Chemical Name | Methyl (3β,7α)-3-((4-((pyridin-2-ylmethyl)amino)butyl)amino)-7-hydroxycholan-24-oate |
| InChl Key | RVANDQULNPITCN-DHKCSNTESA-N |
| InChl Code | InChI=1S/C35H57N3O3/c1-24(10-13-32(40)41-4)28-11-12-29-33-30(15-17-35(28,29)3)34(2)16-14-26(21-25(34)22-31(33)39)37-20-8-7-18-36-23-27-9-5-6-19-38-27/h5-6,9,19,24-26,28-31,33,36-37,39H,7-8,10-18,20-23H2,1-4H3/t24-,25?,26+,28-,29+,30+,31-,33+,34+,35-/m1/s1 |
| SMILES Code | C[C@H](CCC(OC)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)CC4C[C@@H](NCCCCNCC5=NC=CC=C5)CC[C@]4(C)[C@@]3([H])CC[C@]12C |
| References | 1) Krishnan N, Felice C, Rivera K, Pappin DJ, Tonks NK. DPM-1001 decreased copper levels and ameliorated deficits in a mouse model of Wilson's disease. Genes Dev. 2018 Jul 1;32(13-14):944-952. 2) Krishnan N, Konidaris KF, Gasser G, Tonks NK. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem. 2018 Feb 2;293(5):1517-1525 |
More info
Novel potent, specific, non-competitive, and orally bioavailable inhibitor of PTP1B, displaying antidiabetic properties associated with enhanced signaling through insulin and leptin receptors in animal models of diet-induced obesity
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