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JH-XI-10-02
AOB17837
CAS: 2209085-22-1
Chemical Name: 1-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-N-((3S,5S,8R,9S,10S,13S,14S,17S)-17-(isoquinolin-7-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-N-methyl-3,6,9,12-tetraoxapentadecan-15-amide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $42.75 | Total: $4,275.00 |
| 1 | 50 | $49.40 | Total: $2,470.00 |
| 1 | 25 | $57.95 | Total: $1,448.75 |
| 1 | 10 | $68.40 | Total: $684.00 |
| 1 | 5 | $80.75 | Total: $403.75 |
Data sheet
| Molecular Formula | C53H69N5O9 |
| Molecular Weight | 920.16 |
| CAS Numbers | 2209085-22-1 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | JH-XI-10-02; JH-XI10-02; JH-XI 10-02; JH-XI-1002; JH-XI1002; JH-XI 1002; JHXI-1002; JHXI1002; JHXI 1002; |
| IUPAC/Chemical Name | 1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)-N-((3S,17S)-17-(isoquinolin-7-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)-N-methyl-3,6,9,12-tetraoxapentadecan-15-amide |
| InChl Key | JECHBTRAPARMGI-IBMRIUJRSA-N |
| InChl Code | InChI=1S/C53H69N5O9/c1-52-19-15-38(32-37(52)9-10-39-42-12-11-41(53(42,2)20-16-43(39)52)35-8-7-34-17-21-54-33-36(34)31-35)57(3)47(60)18-23-64-25-27-66-29-30-67-28-26-65-24-22-55-44-6-4-5-40-48(44)51(63)58(50(40)62)45-13-14-46(59)56-49(45)61/h4-8,17,21,31,33,37-39,41-43,45,55H,9-16,18-20,22-30,32H2,1-3H3,(H,56,59,61)/t37?,38-,39?,41+,42?,43?,45?,52?,53?/m0/s1 |
| SMILES Code | O=C(N([C@H]1CCC2(C)C3CCC4(C)[C@@H](C5=CC6=C(C=C5)C=CN=C6)CCC4C3CCC2C1)C)CCOCCOCCOCCOCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O |
| References | 1) Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 John M. Hatcher, Eric S. Wang, Liv Johannessen, Nicholas Kwiatkowski, Taebo Sim and Nathanael S. Gray Publication Date (Web): March 18, 2018 (Letter) |
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Novel potent and selective CDK8 degrader
