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VX-765 (Belnacasan)
AOB87376
CAS: 273404-37-8
Chemical Name: Belnacasan; (2S)-1-[(2S)-2-[(4-Amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $8.55 | Total: $855.00 |
| 1 | 50 | $9.88 | Total: $494.00 |
| 1 | 25 | $11.59 | Total: $289.75 |
| 1 | 10 | $13.68 | Total: $136.80 |
| 1 | 5 | $16.15 | Total: $80.75 |
Data sheet
| Molecular Formula | C24H33ClN4O6 |
| Molecular Weight | 508.99 |
| CAS Numbers | 273404-37-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 99% (HPLC) |
| Synonym | VX 765, VX765, VX-765, Belnacasan |
| IUPAC/Chemical Name | (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide |
| InChl Key | SJDDOCKBXFJEJB-MOKWFATOSA-N |
| InChl Code | InChI=1S/C24H33ClN4O6/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13/h8-9,11,16-17,19,23H,5-7,10,12,26H2,1-4H3,(H,27,32)(H,28,31)/t16-,17-,19+,23+/m0/s1 |
| SMILES Code | O=C([C@H]1N(C([C@@H](NC(C2=CC=C(N)C(Cl)=C2)=O)C(C)(C)C)=O)CCC1)N[C@@H](C3)[C@H](OCC)OC3=O |
| References | 1) Noe FM, Polascheck N, Frigerio F, Bankstahl M, Ravizza T, Marchini S, Beltrame L, Banderó CR, Löscher W, Vezzani A. Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy. Neurobiol Dis. 2013 Nov;59:183-93. 2) Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI). Epilepsy Res. 2013 Jan;103(1):2-30. |
More info
A novel Caspase-1 inhibitor being investigated for the treatment of epilepsy
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