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LB-100
AOB4037
CAS No:1113025-87-8
Chemical Name: LB 1; (1R,2R,3S,4S)-rel-3-[(4-Methyl-1-piperazinyl)carbonyl]-7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $7.65 | Total: $765.00 |
| 1 | 50 | $8.84 | Total: $442.00 |
| 1 | 25 | $10.37 | Total: $259.25 |
| 1 | 10 | $12.24 | Total: $122.40 |
| 1 | 5 | $14.45 | Total: $72.25 |
Data sheet
| Molecular Formula | C13H20N2O4 |
| Molecular Weight | 268.31 |
| CAS Numbers | 1113025-87-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 3-[(4-Methylpiperazin-1-yl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid |
| InChl Key | JUQMLSGOTNKJKI-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C13H20N2O4/c1-14-4-6-15(7-5-14)12(16)10-8-2-3-9(19-8)11(10)13(17)18/h8-11H,2-7H2,1H3,(H,17,18) |
| SMILES Code | O=C(C1C(O2)CCC2C1C(N3CCN(C)CC3)=O)O |
| References | 1) Fu QH, etc. LB-100 sensitizes hepatocellular carcinoma cells to the effects of sorafenib during hypoxia by activation of Smad3 phosphorylation. Tumour Biol. 2016 Jun;37(6):7277-86. 2) Chung V, etc, Tolerability, and Preliminary Activity of LB-100, an Inhibitor of Protein Phosphatase 2A, in Patients with Relapsed Solid Tumors: An Open-Label, Dose Escalation, First-in-Human, Phase I Trial. Clin Cancer Res. 2016 Dec 30. 3) Bai XL, Zhang Q, Ye LY, Hu QD, Fu QH, Zhi X, Su W, Su RG, Ma T, Chen W, Xie SZ, Chen CL, Liang TB. Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas. Mol Cancer Ther. 2014 Aug;13(8):2062-72. |
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