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Transcription Factors
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View larger NRX-252262
AOB17865
CAS: N/A
Chemical Name: 4-((2,6-Dichlorophenyl)thio)-3-(5,6-dimethoxyisoindoline-2-carbonyl)-6-(trifluoromethyl)pyridin-2(1H)-one
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $41.65 | Total: $208.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 100 | $22.05 | Total: $2,205.00 |
Data sheet
| Molecular Formula | C23H17Cl2F3N2O4S |
| Molecular Weight | 545.35 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 4-((2,6-Dichlorophenyl)thio)-3-(5,6-dimethoxyisoindoline-2-carbonyl)-6-(trifluoromethyl)pyridin-2(1H)-one |
| SMILES Code | O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1 |
| References | 1) Kyle R. Simonetta, et al., Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction, Nature Communications volume 10, Article number: 1402 (2019) |
More info
Novel potent enhancer of the interaction between an oncogenic transcription factor, β-Catenin, and its cognate E3 ligase, SCFβ-TrCP
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