Quantity | = | Concentration | x | Volume | x | Molecular Weight |
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1) Click the Molarity Calculation Cart® button.
2) Specify the Concentration and Volume of your desired Molarity.
3) Click Calculate.
4) Your desired Quantity will be calculated and will be put under Quantity: (only for mg)
5) Click Add to Cart and then Proceed to checkout to complete the order. You will receive the quantity as you ordered as solvent-free form.
Alert: If you want to make a solution with a solvent (such DMSO), please add instructions in the notes section (such as 10 nM/1 mL in DMSO) and we will pack and deliver the product as a solution (such as 10 nM solution in 1 mL DMSO). If the product cannot be dissolved in DMSO or you would like to specify your own preferred solvent, please add detailed instructions in the notes section. All solutions must be shipped with an ice bag, costing an additional fee of $20 for S&H.
AOB36697
CAS: 2146095-85-2
AOBIOUS launched this product in 2018
CITATIONS - Publications That Use AOBIOUS Product
1) J Clin Invest. 2021 Aug 2; 131(15): e138022.
2) Cell Metabolism, V31(5), P920-936.E7, MAY 05, 2020
3) Aus dem Institut für Medizinische Mikrobiologie und Krankenhaushygiene (2022)
Analog of AOB31454
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Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
---|---|---|---|
1 | 100 | $11.25 | Total: $1,125.00 |
1 | 50 | $13.00 | Total: $650.00 |
1 | 25 | $15.25 | Total: $381.25 |
1 | 10 | $18.00 | Total: $180.00 |
1 | 5 | $21.25 | Total: $106.25 |
Molecular Formula | C24H24N4O2 |
Molecular Weight | 400.47 |
CAS Numbers | 2146095-85-2 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO |
Purity | 98% by HPLC |
IUPAC/Chemical Name | 6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile |
InChl Key | VVVOFJZXKJKHTD-UHFFFAOYSA-N |
SMILES Code | CC(C1(C2=CC(C3=CC=CC=C3)=CC(CO)=C2)C4=C(OC(N)=C1C#N)NN=C4C)C |
References | 1) Ducker et al (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc.Natl.Acad.Sci.U.S.A. 114 11404 PMID: 29073064 |
Serine hydroxymethyltransferase (SHMT) inhibitor, potently inhibiting both human SHMT1/2.
Also check SHMT-IN-2 (AOB31454) and SHIN2 (AOB11286) two close analogs of SHIN1 that share the same pharmacological profile.