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SHIN1
AOB36697
CAS: 2146095-85-2
AOBIOUS launched this product in 2018
CITATIONS - Publications That Use AOBIOUS Product
1) J Clin Invest. 2021 Aug 2; 131(15): e138022.
2) Cell Metabolism, V31(5), P920-936.E7, MAY 05, 2020
3) Aus dem Institut für Medizinische Mikrobiologie und Krankenhaushygiene (2022)
Analog of AOB31454
Molarity Calculation Cart®
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $11.25 | Total: $1,125.00 |
| 1 | 50 | $13.00 | Total: $650.00 |
| 1 | 25 | $15.25 | Total: $381.25 |
| 1 | 10 | $18.00 | Total: $180.00 |
| 1 | 5 | $21.25 | Total: $106.25 |
Data sheet
| Molecular Formula | C24H24N4O2 |
| Molecular Weight | 400.47 |
| CAS Numbers | 2146095-85-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile |
| InChl Key | VVVOFJZXKJKHTD-UHFFFAOYSA-N |
| SMILES Code | CC(C1(C2=CC(C3=CC=CC=C3)=CC(CO)=C2)C4=C(OC(N)=C1C#N)NN=C4C)C |
| References | 1) Ducker et al (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc.Natl.Acad.Sci.U.S.A. 114 11404 PMID: 29073064 |
More info
Serine hydroxymethyltransferase (SHMT) inhibitor, potently inhibiting both human SHMT1/2.
Also check SHMT-IN-2 (AOB31454) and SHIN2 (AOB11286) two close analogs of SHIN1 that share the same pharmacological profile.
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