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Enzyme Inhibitors

SHIN1 View larger

SHIN1

AOB36697

349 Items

Analog of AOB31454

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$25.00

$25.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $21.25 Total: $106.25
110 $18.00 Total: $180.00
125 $15.25 Total: $381.25
150 $13.00 Total: $650.00
1100 $11.25 Total: $1,125.00

Data sheet

Molecular FormulaC24H24N4O2
Molecular Weight400.47
CAS Numbers2146095-85-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile
InChl KeyVVVOFJZXKJKHTD-UHFFFAOYSA-N
SMILES CodeCC(C1(C2=CC(C3=CC=CC=C3)=CC(CO)=C2)C4=C(OC(N)=C1C#N)NN=C4C)C
References1) Ducker et al (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc.Natl.Acad.Sci.U.S.A. 114 11404 PMID: 29073064

More info

Serine hydroxymethyltransferase (SHMT) inhibitor, potently inhibiting both human SHMT1/2.

Also check SHMT-IN-2 (AOB31454) and SHIN2 (AOB11286) two close analogs of SHIN1 that share the same pharmacological profile.

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