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Kinase Inhibitors

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NVP-2

AOB8254

CAS: 1263373-43-8

 

Chemical Name: NVP2; 4-[[[6-[5-Chloro-2-[[4-[[(2R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]pyridin-4-yl]pyridin-2-yl]amino]methyl]oxane-4-carbonitrile

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$37.50

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $16.88 Total: $1,687.50
150 $19.50 Total: $975.00
125 $22.88 Total: $571.88
110 $27.00 Total: $270.00
15 $31.88 Total: $159.38

Data sheet

Molecular FormulaC27H37ClN6O2
Molecular Weight513.07
CAS Numbers1263373-43-8
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO or EtOH 51.31 mg per 1 mL
Purity98% by HPLC
IUPAC/Chemical Name4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile
InChl KeyXWQVQSXLXAXOPJ-QNGMFEMESA-N
SMILES CodeCOC[C@H](N[C@H]1CC[C@H](NC2=CC(C3=NC(NCC4(C#N)CCOCC4)=CC=C3)=C(C=N2)Cl)CC1)C
References1) Olson et al (2018) Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat.Chem.Biol. 14 163 PMID: 29251720

2) Winter et al (2017) BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment. Mol.Cell 67 5 PMID: 28673542
PubChem ID66937006

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Novel selective and ATP-competitive inhibitor of the cyclin-dependent kinase CDK9















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