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View larger K-Rhein
AOB11188
CAS: 478-43-3 (non-salt parent)
Chemical Name: Rhein triporassium salt; 4,5-Dihydroxyanthraquinone-2-carboxylic acid tripottasium salt
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $50.15 | Total: $250.75 |
| 1 | 10 | $42.48 | Total: $424.80 |
| 1 | 25 | $35.99 | Total: $899.75 |
| 1 | 50 | $30.68 | Total: $1,534.00 |
| 1 | 100 | $26.55 | Total: $2,655.00 |
Data sheet
| Molecular Formula | C15H5K3O6 |
| Molecular Weight | 398.49 |
| CAS Numbers | 478-43-3 (non-salt parent) |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO Aqueous |
| Purity | 95% by HPLC |
| Synonym | Potasium Rhein; Rhein K; Rhein Tripotasium |
| IUPAC/Chemical Name | 4,5-Dihydroxyanthraquinone-2-carboxylic acid tripottasium salt |
| References | 1) Eran Blacher et al., Inhibition of glioma progression by a newly discovered CD38 inhibitor; IJC, 136:1422 (2015) |
More info
K-Rhein, also known as rhein tripotassium salt (CAS 478-43-3), is a synthetic derivative of rhein, a naturally occurring anthraquinone compound found in plants like Rheum palmatum (rhubarb) and Cassia tora. K-Rhein is primarily utilized in research to study its effects on various biological processes, particularly its role in inhibiting the enzyme CD38 that affects NAD⁺ metabolism, calcium signaling, and downstream cellular processes, making it a valuable tool in neuroprotection, metabolic research, and epigenetic studies. Its use is research-only, with no approved clinical applications.
Mechanism of Action
K-Rhein functions as a CD38 inhibitor. CD38 is an enzyme involved in the metabolism of NAD+ and the regulation of intracellular calcium levels. By inhibiting CD38, K-Rhein can influence cellular processes such as energy metabolism, immune response, and neuroprotection.
Biological/Functional Effects
| Functional Area | Effect of K-Rhein |
|---|---|
| Calcium signaling | Reduces intracellular calcium flux via CD38 inhibition |
| Energy metabolism | Maintains NAD⁺ levels, potentially improving mitochondrial function |
| Neuroprotection | In preclinical studies, protects neurons from oxidative stress and excitotoxicity |
| Immune modulation | CD38 inhibition can affect immune cell activation and cytokine release |
| Metabolic research | Used to study NAD⁺-dependent pathways, aging, and metabolic diseases |
Functional Applications
CD38 Inhibition: K-Rhein is used to study the effects of CD38 inhibition on cellular functions and its potential therapeutic applications.
Neuroprotection: Research suggests that K-Rhein may have neuroprotective effects, potentially offering insights into treatments for neurodegenerative diseases.
Metabolic Studies: By modulating NAD+ metabolism, K-Rhein serves as a tool to explore metabolic pathways and their implications in various diseases.
Caution
While K-Rhein is a valuable research tool, its use is primarily confined to laboratory settings. Its pharmacokinetics and potential side effects in humans are not well-studied, and it is not approved for clinical use.
