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PLX4720

AOB87700

CAS: 918505-84-7

 

Chemical Name: PLX-4720; N-[3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]propane-1-sulfonamide

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$15.00

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $6.75 Total: $675.00
150 $7.80 Total: $390.00
125 $9.15 Total: $228.75
110 $10.80 Total: $108.00
15 $12.75 Total: $63.75

Data sheet

Molecular FormulaC17H14ClF2N3O3S
Molecular Weight413.83
CAS Numbers918505-84-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity 99% (HPLC)
SynonymPLX 4720; PLX4720; PLX-4720.
IUPAC/Chemical NameN-(3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
InChl KeyYZDJQTHVDDOVHR-UHFFFAOYSA-N
InChl CodeInChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)
SMILES CodeCCCS(=O)(NC1=CC=C(F)C(C(C2=CNC3=NC=C(Cl)C=C32)=O)=C1F)=O
References1) Kamata T, et al. Hematopoietic expression of oncogenic BRAF promotes aberrant growth of monocyte-lineage cells resistant to PLX4720. Mol Cancer Res. 2013 Dec;11(12):1530-41. doi: 10.1158/1541-7786.MCR-13-0294. Epub 2013 Oct 23. PubMed PMID: 24152792; PubMed Central PMCID: PMC3869667.

2) Eum KH, Ahn SK, Kang H, Lee M. Differential inhibitory effects of two Raf-targeting drugs, sorafenib and PLX4720, on the growth of multidrug-resistant cells. Mol Cell Biochem. 2013 Jan;372(1-2):65-74. doi: 10.1007/s11010-012-1446-0. Epub 2012 Sep 2. PubMed PMID: 22941213.

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